The HB EGF Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HBEGF. This antibody recognizes Human, Mouse, and Rat antigen. The HB EGF Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Post Translational Modifications: Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.
Subcellular Location: Secreted>Extracellular space. Note: Mature HB-EGF is released into the extracellular space and probably binds to a receptor.Cell membrane>Single-pass type I membrane protein.
Subunit Structure: Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4